RalGPS2 (Ral GEF with PH domain and SH3 binding motif 2) is a guanine nucleotide exchange factor for RalA GTPase. It is expressed in testis and brain.
Function:
Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity).
Subunit:
Interacts with the SH3 domains of GRB2 and PLCG1. Interacts with RALA.
Subcellular Location:
Cell Membrane and Cytoplasmic. Associates with membranes through the PH domain.
DISEASE:
RALGPS2 is a potential candidate gene for susceptibility to Alzheimer disease linked to 1q24.
SWISS:
Q86X27
Gene ID:
55103
Database links:
Entrez Gene: 424429 Chicken
Entrez Gene: 457549 Chimpanzee
Entrez Gene: 100052879 Horse
Entrez Gene: 55103 Human
Entrez Gene: 78255 Mouse
Entrez Gene: 304887 Rat
Entrez Gene: 717165 Rhesus monkey
Entrez Gene: 779506 Xenopus tropicalis
Entrez Gene: 393446 Zebrafish
SwissProt: Q5ZJK0 Chicken
SwissProt: Q4R7W3 Cynomolgus Monkey
SwissProt: Q86X27 Human
SwissProt: Q9ERD6 Mouse
Unigene: 632485 Human
Unigene: 28376 Mouse
Unigene: 224486 Rat
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Paraformaldehyde-fixed, paraffin embedded (rat liver tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RALGPS2) Polyclonal Antibody, Unconjugated (SL21178R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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