Rabbit Anti-TIPRL antibody | Sunlong Medical

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1810011K17Rik; dJ69E11.3; MGC3794; Putative MAPK activating protein PM10; Putative MAPK-activating protein PM10; RP1-69E11.1; Tip; TIP41; TIP41-like protein; tiprl; TIPRL_HUMAN; TOR Signaling Pathway Regulator like; Type 2A-interacting protein

Cat:

SL19121R

Species Reactivity：

Mouse,(predicted: Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human TIPRL:51-150/272

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Spleen (Mouse) Lysate at 40 ugPrimary: Anti-TIPRL (SL19121R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 31 kDObserved band size: 31 kD

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]

Function:
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

Subunit:
Isoform 1 interacts with PPP2CA. Isoform 2 does notinteract with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C.Interacts with IGBP1; the interaction is dependent on PPP2CA.Associates with a protein phosphatase 2A PP2A(C):alpha-4 complex.

Subcellular Location:
Cytoplasm.

Similarity:
Belongs to the TIP41 family.

SWISS:
O75663

Gene ID:
261726

Database links:

Entrez Gene: 261726 Human

Entrez Gene: 226591 Mouse

Entrez Gene: 72869 Rat

Omim: 62367 Human

SwissProt: O75663 Human

SwissProt: Q8SH58 Mouse

SwissProt: A2VCX1 Rat

Unigene: 209431 Human

Unigene: 21520 Mouse

Unigene: 56867 Rat

Picture

Sample:
Spleen (Mouse) Lysate at 40 ug
Primary: Anti-TIPRL (SL19121R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 31 kD

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