Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
Function:
May function in the regulation of alternative or illicit splicing.
Subcellular Location:
Nucleus > nucleoplasm. Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the RRM Spen family.
Contains 3 RRM (RNA recognition motif) domains.
Contains 1 SPOC domain.
SWISS:
Q8NDT2
Gene ID:
109095
Database links:
Entrez Gene: 29890 Human
Entrez Gene: 109095 Mouse
Entrez Gene: 315988 Rat
Omim: 612602 Human
SwissProt: Q8NDT2 Human
SwissProt: Q6PHZ5 Mouse
Unigene: 118738 Human
Unigene: 431589 Mouse
| Picture |
Paraformaldehyde-fixed, paraffin embedded (Human stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RBM15B) Polyclonal Antibody, Unconjugated (SL21289R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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