Rabbit Anti-phospho-Fos B (Ser27) antibody

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Fos B (phospho S27); p-Fos B (phospho S27); p-FosB (phospho S27); FBJ murine osteosarcoma viral oncogene homolog B; FOS B; FOS-B; FBJ osteosarcoma oncogene B; FosB; G0/G1 switch regulatory protein 3; G0S3; GOS3; GOSB; MGC42291; Oncogene FOS B; Protein fos

Cat:

SL20664R

Species Reactivity：

Mouse,(predicted: Human,Rat,Dog,Cow,Horse,Sheep,Guinea Pig,)

Immunogen：

KLH conjugated synthesised phosphopeptide derived from human Fos B around the phosphorylation site of Ser27:QYL(p-S)SV

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample:Cerebrum (Mouse) Lysate at 40 ugPrimary: Anti-phospho-Fos B (Ser27)(SL20664R)at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 36kDObserved band size: 36kD

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Unit:

Price: $256.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.

Function:
FosB interacts with Jun proteins enhancing their DNA binding activity.

Subunit:
Heterodimer.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the bZIP family. Fos subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.

SWISS:
P53539

Gene ID:
2354

Database links:

Entrez Gene: 2354 Human

Entrez Gene: 14282 Mouse

Entrez Gene: 10072176 Rat

Omim: 164772 Human

SwissProt: P53539 Human

SwissProt: P13346 Mouse

Unigene: 590958 Human

Unigene: 248335 Mouse

Picture

Sample:Cerebrum (Mouse) Lysate at 40 ug
Primary: Anti-phospho-Fos B (Ser27)(SL20664R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36kD
Observed band size: 36kD

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