The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008].
Function:
Somatostatin inhibits the release of somatotropin.
Subcellular Location:
Secreted.
Similarity:
Belongs to the somatostatin family.
SWISS:
P61278
Gene ID:
6750
Database links:
Entrez Gene: 396279 Chicken
Entrez Gene: 280932 Cow
Entrez Gene: 6750 Human
Entrez Gene: 20604 Mouse
Entrez Gene: 24797 Rat
Omim: 182450 Human
SwissProt: P33094 Chicken
SwissProt: P26917 Cow
SwissProt: P61278 Human
SwissProt: P60041 Mouse
SwissProt: P60042 Rat
Unigene: 1489 Human
Unigene: 34418 Rat
| Picture |
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Somatostatin) Polyclonal Antibody, Unconjugated (SL37040R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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