This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Kidney specific.
Similarity:
Contains 6 cadherin domains.
SWISS:
O75309
Gene ID:
1014
Database links:
Entrez Gene: 489770 Dog
Entrez Gene: 1014 Human
Entrez Gene: 12556 Mouse
Entrez Gene: 100328594 Rabbit
Entrez Gene: 307614 Rat
Omim: 603118 Human
SwissProt: O75309 Human
SwissProt: O88338 Mouse
SwissProt: Q28634 Rabbit
Unigene: 513660 Human
Unigene: 19423 Mouse
Unigene: 3478 Rat
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Sample:
A549(Human) Cell Lysate at 30 ug
Primary: Anti-Cadherin 16 (SL24303R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 90 kD
Observed band size: 95 kD
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