The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq].
Function:
Can transform NIH 3T3 cells from a human stomach tumor (hst) and from karposi's sarcoma (KS3). It has a mitogenic activity.
Subunit:
Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
Subcellular Location:
Secreted.
Similarity:
Belongs to the heparin-binding growth factors family.
SWISS:
P08620
Gene ID:
2249
Database links:
Entrez Gene: 2249 Human
Entrez Gene: 14175 Mouse
Entrez Gene: 116499 Rat
Omim: 164196 Human
SwissProt: P08620 Human
SwissProt: P11403 Mouse
Unigene: 1755 Human
Unigene: 4956 Mouse
Unigene: 81223 Rat
转录调节因子（Transcriptin Regulators）
纤维母细胞生长因子4是FGF家族的chengyu7成员。FGF家族参与一系列的生理功能：胚胎发育、细胞生长、器官形成、组织修复、肿瘤生长和侵袭。FGF3/FGF4在很多恶性肿瘤中呈高表达，被认为原癌基因之一。
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