This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.
Function:
GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development. Contributes to the regulation of dendritic branching and filopodia extension.
Subunit:
Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C and UACA. Interacts with NCS1/FREQ at the plasma membrane. Interacts with RAB11FIP3 and RAB11FIP4. Interacts with USP6 (via Rab-GAP TBC domain). Interacts with ECM29. Interacts with TBC1D24.
Subcellular Location:
Golgi apparatus. Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor. Cell membrane. Cell projection, filopodium membrane; Lipid-anchor. Note=Recruited to the cell membrane in association with CYTH2 and ARL4C.
Similarity:
Belongs to the small GTPase superfamily. Arf family.
SWISS:
P62330
Gene ID:
382
Database links:
Entrez Gene: 382 Human
Entrez Gene: 11845 Mouse
Entrez Gene: 780425 Pig
Entrez Gene: 79121 Rat
Omim: 600464 Human
SwissProt: P26990 Chicken
SwissProt: P62330 Human
SwissProt: P62331 Mouse
SwissProt: Q007T5 Pig
SwissProt: P62332 Rat
Unigene: 525330 Human
Unigene: 719973 Human
Unigene: 27308 Mouse
Unigene: 6993 Rat
ARF6主要用于：肿瘤方面的研究，在很多肿瘤组织中都有一定的表达及分布。
技术背景：rRNA 加工、内质网高尔基膜泡介导运输、细胞运动性、细胞附着、小GTP 酶介导信号转导、蛋白运输、膜泡介导运输、正调控肌动蛋白丝聚合、皮层肌动蛋白细胞骨架组织和生物发生、褶边组织和生物发生、调控Rac 蛋白信号转导、负调控受体介导胞吞.
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