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Rabbit Anti-Chromogranin B antibody
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009].
Function:
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
Subcellular Location:
Secreted. Note=Neuroendocrine and endocrine secretory granules.
Tissue Specificity:
Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.
Post-translational modifications:
Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues.
O-glycosylated.
Similarity:
Belongs to the chromogranin/secretogranin protein family.
SWISS:
P16014
Gene ID:
12653
Database links:
Entrez Gene: 1114 Human
Entrez Gene: 12653 Mouse
Entrez Gene: 24259 Rat
Omim: 118920 Human
SwissProt: P05060 Human
SwissProt: P16014 Mouse
SwissProt: O35314 Rat
Unigene: 516874 Human
Unigene: 11090 Rat
嗜铬粒素B在肾上腺 垂体 胸腺 子宫 卵巢等神经内分泌组织表达该蛋白成分较多。
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