This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimers disease.
Function:
Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity).
Subunit:
Interacts with RNF10.
Subcellular Location:
Nucleus. Nucleus speckle.
Similarity:
Contains 1 homeobox DNA-binding domain.
SWISS:
P50222
Gene ID:
4223
Database links:
Entrez Gene: 4223 Human
Entrez Gene: 17286 Mouse
Entrez Gene: 29279 Rat
Omim: 600535 Human
SwissProt: P50222 Human
SwissProt: P32443 Mouse
SwissProt: P39020 Rat
Unigene: 170355 Human
Unigene: 341398 Mouse
Unigene: 34890 Rat
Gax主要在血管平滑肌细胞和内皮细胞中表达的同源异形盒基因,但Gax基因过表达可以抑制血管平滑肌细胞和内皮细胞的增殖，Gax也是脊椎动物肢体发育的重要调节因子，目前除用于心血管方面的研究，也用于肿瘤血管方面的探索。
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