ACY3 belongs to the aspA/astE family. Aspartoacylase subfamily. Catalytic activity: N-acyl-L-aspartate + H(2)O = a carboxylate + L-aspartate. Plays an important role in deacetylating mercapturic acids in kidney proximal tubules.
Function:
Plays an important role in deacetylating mercapturic acids in kidney proximal tubules.
Subunit:
Homotetramer. Interacts with HCV core protein.
Subcellular Location:
Apical cell membrane; Peripheral membrane protein. Cytoplasm. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.
Similarity:
Belongs to the AspA/AstE family. Aspartoacylase subfamily.
SWISS:
Q96HD9
Gene ID:
91703
Database links:
Entrez Gene: 91703 Human
Entrez Gene: 71670 Mouse
SwissProt: Q96HD9 Human
SwissProt: Q91XE4 Mouse
Unigene: 126265 Human
Unigene: 29735 Mouse
HCV核结合蛋白1主要用于丙肝病毒的研究.
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