Human Rad1 is a component of a heterotrimeric PCNA like complex that also contains the Rad9 and Hus1 proteins. This complex is believed to be involved in cellular responses to DNA damage, possibly by associating with Rad17 and several components of the PCNA-loading heteropentamer, replication factor C. Human Rad1 exhibits significant homology to Rad1 from S. pombe, and its expression in yeast rad1 mutants has been shown to partially restore radiation resistance and G2 checkpoint activity. It has also been shown to possess exonuclease activity.
Function:
May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
Subunit:
Interacts with calmodulin preferentially in the inactive, GDP-bound form. Binds CAMKII which is capable of phosphorylating RAD in vitro. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane (By similarity).
Subcellular Location:
Cell membrane.
Tissue Specificity:
Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.
Similarity:
Belongs to the small GTPase superfamily. RGK family.
SWISS:
P55042
Gene ID:
6236
Database links:
Entrez Gene: 6236 Human
Entrez Gene: 56437 Mouse
Entrez Gene: 83521 Rat
Omim: 179503 Human
SwissProt: P55042 Human
SwissProt: O88667 Mouse
SwissProt: P55043 Rat
Unigene: 1027 Human
Unigene: 29467 Mouse
Unigene: 11189 Rat
该抗体是与糖尿病的胰岛素抵抗研究有关的蛋白。
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