SLC8A3 is a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner.
Function:
Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.
Similarity:
Belongs to the sodium/potassium/calcium exchangerv family. SLC8 subfamily.
Contains 2 Calx-beta domains.
SWISS:
P57103
Gene ID:
6547
Database links:
Entrez Gene: 6547 Human
Entrez Gene: 110893 Mouse
Entrez Gene: 140448 Rat
Omim: 607991 Human
SwissProt: P57103 Human
SwissProt: P70549 Rat
Unigene: 337696 Human
Unigene: 443748 Mouse
Unigene: 67030 Rat
钠钙交换蛋白又称钠钙交换体，有三种同分异构体,即NCX1、NCX2和NCX3。3型Na-Ca交换蛋白-NCX3, 主要在脑组织表达，分布与胞浆及胞膜。
|
|
