The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (SFLS), making it a possible candidate gene for familial cases of the SFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Fibroblast growth factor 13 (FGF13) is probably involved in nervous system development and function. Alternative splicing of this gene results in several transcript variants encoding different isoforms with different N-termini.
Tissue Specificity:
Nervous system.
Similarity:
Belongs to the heparin-binding growth factors family.
SWISS:
Q92913
Gene ID:
2258
Database links:
Entrez Gene: 2258 Human
Entrez Gene: 14168 Mouse
Entrez Gene: 84488 Rat
Omim: 300070 Human
SwissProt: Q92913 Human
SwissProt: P70377 Mouse
SwissProt: Q9ERW3 Rat
Unigene: 6540 Human
Unigene: 7995 Mouse
Unigene: 15709 Rat
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