EGFL7 (EGF-like domain-containing protein 7) regulates vascular tubulogenesis in vivo. During sprouting angiogenesis, groups of endothelial cells (ECs) migrate together in units called sprouts. EGFL7 regulates the proper spatial organization of ECs within each sprout and influences their collective movement. It inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro.
Function:
Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro.
Subcellular Location:
Secreted (By similarity).
Tissue Specificity:
Expressed specifically by endothelial cells of the highly vascularized organs heart, lung and kidney.
Similarity:
Contains 2 EGF-like domains.
Contains 1 EMI domain.
SWISS:
Q9QXT5
Gene ID:
353156
Database links:
Entrez Gene: 51162 Human
Entrez Gene: 353156 Mouse
Omim: 608582 Human
SwissProt: Q9UHF1 Human
Unigene: 91481 Human
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