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Rabbit Anti-Midkine antibody
Midkine exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Its expression is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines.
Function:
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).
Subunit:
Homodimer. Interacts with ALK.
Subcellular Location:
Secreted.
Similarity:
Belongs to the pleiotrophin family.
SWISS:
P21741
Gene ID:
4192
Database links:
Entrez Gene: 280852 Cow
Entrez Gene: 4192 Human
Entrez Gene: 17242 Mouse
Entrez Gene: 81517 Rat
Omim: 162096 Human
SwissProt: P21741 Human
SwissProt: P12025 Mouse
SwissProt: Q9R1S9 Rat
Unigene: 21528 Cow
Unigene: 82045 Human
Unigene: 906 Mouse
Unigene: 17447 Rat
中期因子(midkine, MK)具有多种生物学功能: 可促进神经轴突
的生长和各种胚胎神经元的存活,做为一种有丝分裂原,与肿瘤的发生密切相关，MK还有较强的
促血管生成特性, 经研究证实, MK可促进内皮细胞增殖并
提高血管的密度，在多种肿瘤组织和肿
瘤患者的血清中的水平都明显升高。MK和多向促激素(p leiotro2
phin, PTN)同属于一类新的结合肝素的生长因子家
族。
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