AGPAT6 is a novel glycerolipid acyltransferase of the ER, which is crucial for the production of milk fat by the mammary gland. It converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
Function:
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.
Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity:
Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis. Relatively low level of expression in lung.
Similarity:
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
SWISS:
Q86UL3
Gene ID:
137964
Database links:
Entrez Gene: 137964 Human
Entrez Gene: 102247 Mouse
Entrez Gene: 290843 Rat
SwissProt: A3FPG8 Cow
SwissProt: Q86UL3 Human
SwissProt: Q8K2C8 Mouse
SwissProt: Q0ZFS7 Rat
Unigene: 355753 Human
Unigene: 200898 Mouse
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