This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Function:
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
Subunit:
Interacts with FANCD2 and PCNA. Interacts with WDR48.
Subcellular Location:
Nucleus.
Post-translational modifications:
Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.
Ubiquitinated; leading to its subsequent proteasomal degradation (By similarity).
Similarity:
Belongs to the peptidase C19 family.
SWISS:
O94782
Gene ID:
7398
Database links:
Entrez Gene: 7398 Human
Omim: 603478 Human
SwissProt: O94782 Human
Unigene: 35086 Human
USP1蛋白是在DNA损伤修复过程中起作用的蛋白分子，可能在癌变的过程中也起到重要作用.
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