his gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Function:
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.
Subunit:
Interacts with CTNNB1.
Subcellular Location:
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons.
Tissue Specificity:
Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).
Similarity:
Belongs to the NDRG family.
SWISS:
Q9UN36
Gene ID:
57447
Database links:
Entrez Gene: 57447 Human
Entrez Gene: 29811 Mouse
Entrez Gene: 171114 Rat
Omim: 605272 Human
SwissProt: Q9UN36 Human
SwissProt: Q9QYG0 Mouse
SwissProt: Q8VBU2 Rat
Unigene: 525205 Human
Unigene: 26722 Mouse
Unigene: 3407 Rat
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