This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]
Function:
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
Subcellular Location:
Cytoplasm, cytosol.
Tissue Specificity:
Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells.
Post-translational modifications:
Phosphorylated in an aortic smooth muscle cell line, following PDGF treatment.
Similarity:
Belongs to the NDRG family.
SWISS:
Q9ULP0
Gene ID:
65009
Database links:
Entrez Gene: 65009 Human
Entrez Gene: 234593 Mouse
Omim: 614463 Human
SwissProt: Q9ULP0 Human
SwissProt: Q8BTG7 Mouse
Unigene: 322430 Human
Unigene: 29846 Mouse
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