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Rabbit Anti-Pleiotrophin antibody
Pleiotrophin is a heparin-binding growth factor involved in the differentiation and proliferation of neuronal tissue during embryogenesis, and also secreted by melanoma and breast carcinoma cells. Pleiotrophin exhibits mitogenic and angiogenic properties and has been shown to influence the vascular supply, expansion and metastasis of tumour cells.
Function:
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
Subunit:
Interacts with ALK and NEK6.
Subcellular Location:
Secreted.
Tissue Specificity:
Osteoblast and brain.
Post-translational modifications:
Phosphorylated by NEK6.
Similarity:
Belongs to the pleiotrophin family.
SWISS:
P21246
Gene ID:
5764
Database links:
Entrez Gene: 5764 Human
Entrez Gene: 19242 Mouse
Entrez Gene: 24924 Rat
Omim: 162095 Human
SwissProt: P21246 Human
SwissProt: P63089 Mouse
SwissProt: P63090 Rat
Unigene: 371249 Human
Unigene: 279690 Mouse
Unigene: 1653 Rat
多效生长因子(pleiotrophin）是一种分泌性的生长因子,具有促进肿瘤细胞的增殖与迁移，对肿瘤血管的生成有促进作用。
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