Rabbit Anti-Sema6A antibody

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semaphorin 6A; Sema Q; Sema VIA; SEMA6A-1; Semaphorin 6A-1; Semaphorin Q; Semaphorin VIA; HT018; SEM6A_HUMAN; SEMA; Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; SEMA6A 1; Sema6a; SEMA6A1; Semaphorin 6A 1; Semaphorin Q;

Cat:

SL2701R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human Sema6A:301-400/1030<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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SEMA6A belongs to a subfamily characterized by an extracellular semaphorin domain, a transmembrane domain, and a long cytoplasmic tail. Members of this class can repel sympathetic and dorsal root ganglion axons in vitro, consistent with a traditional role as guidance signals. However, the length of the cytoplasmic tail, which includes an EVL-binding site in SEMA6A and an Src-binding site in SEMA6B, suggests that these semaphorins may also function as receptors. SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection. SEMA6A directly links the Ena/VASP and the semaphorin protein families since the SEMA6A protein is capable of selective binding to the protein EVL (Ena/VASP-like protein.

Function:
Can act as repulsive axon guidance cues. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.

Subunit:
Active as a homodimer or oligomer. Interacts with EVL.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.

SWISS:
Q9H2E6

Gene ID:
57556

Database links:

Entrez Gene: 516019 Cow

Entrez Gene: 57556 Human

Entrez Gene: 20358 Mouse

Omim: 605885 Human

SwissProt: Q9H2E6 Human

SwissProt: O35464 Mouse

Unigene: 156967 Human

Unigene: 40909 Mouse

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