Rabbit Anti-SIGLEC6 antibody

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Sialic acid-binding Ig-like lectin 6; CD33L; CD33L1; OBBP1; CDw327; CD327; OBBP1; Full=Sialic acid-binding Ig-like lectin 6; Siglec-6; CD33 antigen-like 1; CDw327 Obesity-binding protein 1; OB-BP1; SIGL6_HUMAN.

Cat:

SL2704R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human SIGLEC6:101-200/453<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Subunit:
Interacts with LEP.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Tissue Specificity:
Expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.

Similarity:
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.

SWISS:
O43699

Gene ID:
946

Database links:

Entrez Gene: 946 Human

Omim: 60885 Human

SwissProt: O43699 Human

Unigene: 720304 Human

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