This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009].
Function:
Non-receptor tyrosine kinase that plays central butdiverse modulatory roles in various signaling processes involved inthe regulation of actin reorganization, cell migration, cellproliferation and survival, cell adhesion, and apoptosis.Participates in signal transduction stimulated by growth factorreceptors, cytokine receptors, G-protein coupled receptors, antigenreceptors and integrins. Induces tyrosine phosphorylation of BCAR1in response to integrin regulation. Activation of BMX by integrinsis mediated by PTK2/FAK1, a key mediator of integrin signalingevents leading to the regulation of actin cytoskeleton and cellmotility. Plays a critical role in TNF-induced angiogenesis, andimplicated in the signaling of TEK and FLT1 receptors, 2 importantreceptor families essential for angiogenesis. Required for thephosphorylation and activation of STAT3, a transcription factorinvolved in cell differentiation. Also involved in interleukin-6(IL6) induced differentiation. Plays also a role in programmingadaptive cytoprotection against extracellular stress in differentcell systems, salivary epithelial cells, brain endothelial cells,and dermal fibroblasts. May be involved in regulation ofendocytosis through its interaction with an endosomal proteinRUFY1. May also play a role in the growth and differentiation ofhematopoietic cells; as well as in signal transduction inendocardial and arterial endothelial cells.
Subunit:
Interacts with BCAR1, CAV1, MYD88, PTK2/FAK1, RUFY1,RUFY2, STAT3, TIRAP and TNFRSF1B.
Subcellular Location:
Cytoplasm. Note=Localizes to the edges ofspreading cells when complexed with BCAR1.
Tissue Specificity:
Highly expressed in cells with great migratorypotential, including endothelial cells and metastatic carcinomacell lines.
Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Contains 1 Btk-type zinc finger.
Contains 1 PH domain.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
SWISS:
P51813
Gene ID:
660
Database links:
Entrez Gene: 660 Human
Entrez Gene: 12169 Mouse
Entrez Gene: 367786 Rat
Omim: 300101 Human
SwissProt: P51813 Human
SwissProt: P97504 Mouse
Unigene: 495731 Human
Unigene: 504 Mouse
Etk属非受体性蛋白酪氨酸激酶BTK家族成员之一，主要表达于上皮和内皮细胞，在调控细胞的增殖及凋亡等信号转导过程中起着重要的作用。Etk与肿瘤发生发展、分化增值密切相关。
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