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Rabbit Anti-UBE1L / UBE2 antibody
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008].
Function:
Activates ubiquitin by first adenylating with ATP its SLCterminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.
Subunit:
Monomer. Binds and is involved in the conjugation of G1P2/ISG15.
Tissue Specificity:
Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.
Similarity:
Belongs to the ubiquitin-activating E1 family.
SWISS:
P41226
Gene ID:
7318
Database links:
Entrez Gene: 7318 Human
Entrez Gene: 74153 Mouse
Entrez Gene: 301000 Rat
Omim: 191325 Human
SwissProt: P41226 Human
Unigene: 16695 Human
Unigene: 277125 Mouse
Unigene: 98275 Rat
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