The Wnt genes are a group of conserved, Cysteine-rich, secreted glycoproteins that are required for numerous developmental processes including embryogenesis, asymmetric cell division and central nervous system (CNS) patterning. Wnt association with the transmembrane spanning receptor frizzled activates dishevelled, which downregulates glycogen synthase kinase (GSK) through serine phosphorylation. Reduced levels of active GSK causes accumulation of b-catenin and subsequent regulation of developmentally significant Wnt target genes. Wnt antagonists such as dickkopf (Dkk), frizzled-related protein (sFRP) and Wnt inhibitory factor-1 (WIF-1), are necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes. WIF-1 is a 379-amino acid secreted protein that contains an N-terminal signal sequence, a 150-amino acid WIF domain, five epidermal growth factor-like repeats and a 45-amino acid SLCterminal hydrophilic domain.
Subcellular Location:
Secreted.
Similarity:
Contains 5 EGF-like domains.
Contains 1 WIF domain.
SWISS:
Q9Y5W5
Gene ID:
11197
Database links:
Entrez Gene: 11197 Human
Entrez Gene: 24117 Mouse
Entrez Gene: 114557 Rat
Omim: 605186 Human
SwissProt: Q9Y5W5 Human
SwissProt: Q9WUA1 Mouse
SwissProt: Q6IN38 Rat
Unigene: 284122 Human
Unigene: 32831 Mouse
Unigene: 74256 Rat
WIF-1(Wnt inhibitory factor-1)属于Wnt分子胞外抑制剂中的sFRP(secreted Frizzled-related protein,sFRP) 家族,通过直接与Wnt分子结合, 而抑制Wnt信号通路活性.
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