Unrip is part of the SMN complex that plays a role in snRNP assembly in the cytoplasm and pre mRNA splicing in the nucleus. Unrip interacts directly with Gemin 6 and Gemin 7 in the SMN complex. It is associated with the complex in the cytoplasm but not in the nucleus and thus is thought to play a role in it's subcellular localisation.
It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
Function:
The SMN complex plays an essential role in spliceosomalsnRNP assembly in the cytoplasm and is required for pre-mRNAsplicing in the nucleus. STRAP may play a role in the cellulardistribution of the SMN complex. Negatively regulates TGF-betasignaling but positively regulates the PDPK1 kinase activity byenhancing its autophosphorylation and by significantly reducing theassociation of PDPK1 with 14-3-3 protein.
Subunit:
Part of the core SMN complex that contains SMN1,GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associateswith the complex in the cytoplasm but not in the nucleus. Alsointeracts with CSDE1/UNR and MAWBP. Interacts with PDPK1.
Subcellular Location:
Cytoplasm. Nucleus. Note=Localizedpredominantly in the cytoplasm but also found in the nucleus.
Similarity:
Belongs to the WD repeat STRAP family.
Contains 7 WD repeats.
SWISS:
Q9Y3F4
Gene ID:
11171
Database links:
Entrez Gene: 11171 Human
Omim: 605986 Human
SwissProt: Q9Y3F4 Human
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