Rabbit Anti-eI4EBP2 antibody

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Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.Full=Eukaryotic translation initiation fact

Cat:

SL3839R

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human 4E-BP2:21-120/120

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

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Other Information
Citations
Protein Attributes
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This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]

Function:
Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.

Subunit:
Nonphosphorylated EIF4EBP2 interacts with EIF4E.

Post-translational modifications:
Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF.

Similarity:
Belongs to the eIF4E-binding protein family.

SWISS:
Q13542

Gene ID:
1979

Database links:

Entrez Gene: 1979 Human

Entrez Gene: 13688 Mouse

Entrez Gene: 361845 Rat

Omim: 602224 Human

SwissProt: Q13542 Human

SwissProt: P70445 Mouse

Unigene: 62240 Human

Unigene: 730236 Human

Unigene: 259516 Mouse

Unigene: 24129 Rat

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