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Rabbit Anti-phospho-IL3RB (Tyr766) antibody
GM-CSF Receptor Beta is the v subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Six transcript variants encoding five different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.
Function:
High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
Subunit:
Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2. Interacts with LYN.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:614370]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Post-translational modifications:
May be phosphorylated by LYN.
Similarity:
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Contains 2 fibronectin type-III domains.
SWISS:
P32927
Gene ID:
1439
Database links:
Entrez Gene: 1439 Human
Entrez Gene: 12983 Mouse
Entrez Gene: 12984 Mouse
Omim: 138981 Human
SwissProt: P32927 Human
SwissProt: P26955 Mouse
Unigene: 285401 Human
Unigene: 592192 Human
Unigene: 235324 Mouse
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