KCNC1 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. It forms a heteromultimer with KCNG3, KCNG4 and KCNV2.
Function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subunit:
Heteromultimer with KCNG3, KCNG4 and KCNV2.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Similarity:
Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.
SWISS:
P48547
Gene ID:
3746
Database links:
Entrez Gene: 3746 Human
Entrez Gene: 16502 Mouse
Entrez Gene: 25327 Rat
Omim: 176258 Human
SwissProt: P48547 Human
SwissProt: P15388 Mouse
SwissProt: P25122 Rat
Unigene: 303870 Human
Unigene: 552896 Human
Unigene: 249386 Mouse
Unigene: 33095 Rat
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