TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta and members of the Toll IL 1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N terminus acts as a dominant negative inhibitor of TGF beta, demonstrating how this protein can function as a mediator between TGF beta receptors and TAK1.
Function:
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Subunit:
Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
Similarity:
Contains 1 PP2SLClike domain.
SWISS:
Q15750
Gene ID:
10454
Database links:
Entrez Gene: 10454 Human
Entrez Gene: 66513 Mouse
Entrez Gene: 315139 Rat
Omim: 602615 Human
SwissProt: Q15750 Human
SwissProt: Q8CF89 Mouse
Unigene: 507681 Human
Unigene: 288245 Mouse
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