PTK9 is an actin-binding protein involved in motile and morphological processes. It inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. PTK9 seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.
Function:
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.
Subunit:
Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated.
Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.
Tissue Specificity:
Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.
Post-translational modifications:
Phosphorylated on serine and threonine residues.
Similarity:
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
Contains 2 ADF-H domains.
SWISS:
Q12792
Gene ID:
5756
Database links:
Entrez Gene: 5756 Human
Entrez Gene: 506683 Cow
Entrez Gene: 19230 Mouse
Entrez Gene: 315265 Rat
Omim: 610932 Human
SwissProt: Q56JV6 Cow
SwissProt: Q12792 Human
SwissProt: Q91YR1 Mouse
SwissProt: Q5RJR2 Rat
Unigene: 5944 Cow
Unigene: 189075 Human
Unigene: 309867 Mouse
Unigene: 162971 Rat
|
|