Rabbit Anti-phospho-PTK9 (Tyr321) antibody

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PTK9 (phospho-Tyr321); PTK9 (phospho-Y321); p-PTK9 (Tyr321); p-TWF1(Y321); A6; A6 protein tyrosine kinase; Protein A6; Protein tyrosine kinase 9; PTK9; PTK9 protein tyrosine kinase 9; TWF 1; TWF1; Twinfilin 1; Twinfilin actin binding protein, homolog 1; T

Cat:

SL5613R

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,)

Immunogen：

KLH conjugated Synthesised phosphopeptide derived from human PTK9 around the phosphorylation site of Tyr321:GD(p-Y)LE

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $256.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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PTK9 is an actin-binding protein involved in motile and morphological processes. It inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. PTK9 seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.

Function:
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.

Subunit:
Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.

Tissue Specificity:
Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.

Post-translational modifications:
Phosphorylated on serine and threonine residues.

Similarity:
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
Contains 2 ADF-H domains.

SWISS:
Q12792

Gene ID:
5756

Database links:

Entrez Gene: 5756 Human

Entrez Gene: 506683 Cow

Entrez Gene: 19230 Mouse

Entrez Gene: 315265 Rat

Omim: 610932 Human

SwissProt: Q56JV6 Cow

SwissProt: Q12792 Human

SwissProt: Q91YR1 Mouse

SwissProt: Q5RJR2 Rat

Unigene: 5944 Cow

Unigene: 189075 Human

Unigene: 309867 Mouse

Unigene: 162971 Rat

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