FGF6 is a secreted heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4.
The FGF6 gene displays oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation.
Function:
Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.
Subunit:
Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
Subcellular Location:
Secreted, extracellular space.
Tissue Specificity:
Leukemia cell lines with platelet/ megakaryocytic differentiation potential.
Similarity:
Belongs to the heparin-binding growth factors family.
SWISS:
P10767
Gene ID:
2251
Database links:
Entrez Gene: 2251 Human
Entrez Gene: 14177 Mouse
Entrez Gene: 170700 Rat
Omim: 134921 Human
SwissProt: P10767 Human
SwissProt: P21658 Mouse
Unigene: 166015 Human
Unigene: 3403 Mouse
Unigene: 81222 Rat
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