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Rabbit Anti-FGFR1OP antibody
FGFR1 Oncogene Partner is required for anchoring microtubules to the centrosomes. Ubiquitous; highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). There are three named isoforms.
Function:
Required for anchoring microtubules to the centrosomes.
Subunit:
Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1.
Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Note=Associated with gamma-tubulin.
Tissue Specificity:
Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.
DISEASE:
Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
Similarity:
Belongs to the FGFR1OP family.
Contains 1 LisH domain.
SWISS:
O95684
Gene ID:
11116
Database links:
Entrez Gene: 11116 Human
Entrez Gene: 75296 Mouse
Entrez Gene: 365103 Rat
Entrez Gene: 683722 Rat
Omim: 605392 Human
SwissProt: Human
SwissProt: O95684 Human
SwissProt: Q66JX5 Mouse
SwissProt: Q4V7C1 Rat
Unigene: 487175 Human
Unigene: 227250 Mouse
Unigene: 166829 Rat
FGFR1OP蛋白最初是在引起干细胞骨髓增生病的癌蛋白中作为FGFR1的融合伴侣被发现的，目前研究认为，FGFR1OP蛋白在很多组织细胞中都有不同的存在，尤其是以脑, 心，肝，肌肉，肾，小肠，结肠，肾上腺，前列腺，睾丸和胰腺中高表达。
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