OVCA1 is required for the first step in the synthesis of diphthamide, a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. OVCA1 is one of several enzymes involved in synthesis of diphthamide in EEF2.
Function:
Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity).
Subunit:
Interacts with DPH2 (By similarity). Interacts with RBM8A.
Subcellular Location:
Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization.
Tissue Specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors.
Similarity:
Belongs to the DPH1/DPH2 family. DPH1 subfamily.
SWISS:
Q9BZG8
Gene ID:
361
Database links:
Entrez Gene: 361 Human
Entrez Gene: 116905 Mouse
Entrez Gene: 287523 Rat
Omim: 603527 Human
SwissProt: Q9BZG8 Human
SwissProt: Q5NCQ5 Mouse
Unigene: 513856 Human
Unigene: 41496 Mouse
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