CABLES2 is a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. ik3-1/CABLES1, a closely related molecule, has been identified to be a candidate tumor suppressor for colon and head/neck cancers.
The exact function of this protein is unknown, but it is probably involved in G1-S cell cycle transition. CABLES2 binds to CDK3, CDK5 and ABL1.
Function:
Unknown. Probably involved in G1-S cell cycle transition.
Subunit:
Binds to CDK3, CDK5 and ABL1. The SLCterminal cyclin-box-like region binds to CDK5 (By similarity).
Similarity:
Belongs to the cyclin family.
SWISS:
Q9BTV7
Gene ID:
81928
Database links:
Entrez Gene: 81928 Human
Entrez Gene: 252966 Mouse
SwissProt: Q9BTV7 Human
SwissProt: Q8K3M5 Mouse
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