Progression of cells from interphase to mitosis involves alterations in cell structures and activities. The transition from G2 to M phase is induced by M phase promoting factor, or MPF. In M phase, many proteins are phosphorylated directly by MPF or indirectly by kinases activated by MPF. These M phase phosphoproteins (MPPs, or MPHOSPHs) permit disassembly of interphase structures and generation of M phase enzymatic activities and structures. VAM1 or MPP6 is thought to be a nucleolus specific exosome co factor, required for its role in the maturation of 5.8S rRNA.
Subunit:
Interacts with CADM1 (By similarity). Interacts with the LIN7 proteins.
Subcellular Location:
Membrane; Peripheral membrane protein (By similarity).
Tissue Specificity:
Abundant in testis, brain, and kidney with lower levels detectable in other tissues.
Similarity:
Belongs to the MAGUK family.
Contains 1 guanylate kinase-like domain.
Contains 2 L27 domains.
Contains 1 PDZ (DHR) domain.
Contains 1 SH3 domain.
SWISS:
Q9NZW5
Gene ID:
51678
Database links:
Entrez Gene: 51678 Human
Entrez Gene: 56524 Mouse
Entrez Gene: 362359 Rat
Omim: 606959 Human
SwissProt: Q9NZW5 Human
SwissProt: Q9JLB0 Mouse
Unigene: 533355 Human
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