FGF22 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development.
Fibroblast Growth Factor-22 stimulates the proliferation and activation of cells that express FGF receptor.
Function:
Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.
Subunit:
Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.
Subcellular Location:
Secreted (Potential).
Similarity:
Belongs to the heparin-binding growth factors family.
SWISS:
Q9HCT0
Gene ID:
27006
Database links:
Entrez Gene: 27006 Human
Entrez Gene: 67112 Mouse
Entrez Gene: 170579 Rat
Omim: 605831 Human
SwissProt: Q9HCT0 Human
SwissProt: Q9ESS2 Mouse
Unigene: 49687 Human
Unigene: 154211 Mouse
Unigene: 198777 Rat
|
|
