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Home > Product > Antibody > Rabbit Anti-PDGF-D/SCDGFB antibody
IEGF; Iris expressed growth factor; Iris-expressed growth factor; MGC26867; MSTP036; PDGF D; PDGF-D; PDGFD; PDGFD latent form; PDGFD receptor-binding form; PDGFD_HUMAN; Platelet derived growth factor D; Platelet-derived growth factor D; receptor-binding f
Cat:
SL5776R
Species Reactivity：
Human,(predicted: Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human SCDGFB:271-370/370
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Sample: Control (-) Cell Lysate at 8 ugHuman PDGF-D (Full Length) Overexpression Cell Lysate at 8ugPrimary: Anti-PDGF-D (SL5776R) at 1/2000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 14/41 kDObserved band size: 41 kD
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Product PDFs
Datasheet:


SCDGFB (Spinal cord derived growth factor B) is a member of the platelet derived growth factor family. It only forms homodimers and does not dimerize with the other three family members. It is a potent mitogen for cells of mesenchymal origin. It is activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet derived growth factor receptor. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. It induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.

Function:
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).

Subunit:
Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.

Subcellular Location:
Secreted. Note=Released by platelets upon wounding.

Tissue Specificity:
Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.

Post-translational modifications:
Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.

Similarity:
Belongs to the PDGF/VEGF growth factor family.
Contains 1 CUB domain.

SWISS:
Q9GZP0

Gene ID:
80310

Database links:

Entrez Gene: 80310 Human

Entrez Gene: 71785 Mouse

Entrez Gene: 66018 Rat

Omim: 609673 Human

SwissProt: Q9GZP0 Human

SwissProt: Q925I7 Mouse

SwissProt: Q9EQT1 Rat

Unigene: 352298 Human

Unigene: 390122 Mouse

Unigene: 64493 Rat



Picture

Sample:
Control (-) Cell Lysate at 8 ug Human PDGF-D (Full Length) Overexpression Cell Lysate at 8ug Primary: Anti-PDGF-D (SL5776R) at 1/2000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 14/41 kD
Observed band size: 41 kD
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