May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Function:
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Subunit:
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
Subcellular Location:
Secreted.
Tissue Specificity:
Glial cells.
Post-translational modifications:
Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step.
DISEASE:
Defects in FGF9 are the cause of multiple synostoses syndrome type 3 (SYNS3) [MIM:612961]. Multiple synostoses syndrome is an autosomal dominant condition characterized by progressive joint fusions of the fingers, wrists, ankles and cervical spine, characteristic facies and progressive conductive deafness.
Similarity:
Belongs to the heparin-binding growth factors family.
SWISS:
P31371
Gene ID:
2254
Database links:
Entrez Gene: 378917 Chicken
Entrez Gene: 2254 Human
Entrez Gene: 1436 Mouse
Entrez Gene: 396717 Pig
Entrez Gene: 25444 Rat
Omim: 600921 Human
SwissProt: P31371 Human
SwissProt: P54130 Mouse
SwissProt: Q95L12 Pig
SwissProt: P36364 Rat
Unigene: 111 Human
Unigene: 8846 Mouse
Unigene: 25174 Rat
|
|
