ABI3 is thought to inhibit tumor metastasis. In vitro, ABI3 reduces cell motility.
Function:
May inhibit tumor metastasis. In vitro, reduces cell motility.
Subunit:
May interact with PAK1 and PAK2. Probably interacts with TARSH.
Subcellular Location:
Cytoplasm. Note=Colocalizes with PAK2 at leading edge of cells.
Tissue Specificity:
Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.
Similarity:
Belongs to the ABI family.
Contains 1 SH3 domain.
SWISS:
Q9P2A4
Gene ID:
51225
Database links:
Entrez Gene: 51225
Human
Entrez Gene: 66610 Mouse
Entrez Gene: 303476 Rat
Omim: 606363 Human
SwissProt: Q9P2A4 Human
SwissProt: Q8BYZ1 Mouse
Unigene: 130719 Human
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