This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene.
Function:
Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility.
Subunit:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum basal body. Golgi apparatus. Note=Associates with microtubules. Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa.
Tissue Specificity:
Expressed in the heart, skeletal muscle, pancreas and liver. Weakly or not expressed in brain, placenta, lung and kidney.
Similarity:
Belongs to the GAS8 family.
SWISS:
O95995
Gene ID:
2622
Database links:
Entrez Gene: 2622 Human
Entrez Gene: 104346 Mouse
Entrez Gene: 361438 Rat
Omim: 605178 Human
SwissProt: O95995 Human
SwissProt: Q60779 Mouse
SwissProt: Q499U4 Rat
Unigene: 431792 Human
Unigene: 117265 Mouse
Unigene: 209051 Rat
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