S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
Function:
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
Subunit:
Binds to the retinoblastoma protein (RB). Interacts with GATA3.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.
Similarity:
Contains 8 C2H2-type zinc fingers.
Contains 1 SET domain.
SWISS:
Q13029
Gene ID:
7799
Database links:
Entrez Gene: 7799 Human
Entrez Gene: 110593 Mouse
Entrez Gene: 313678 Rat
Omim: 601196 Human
SwissProt: Q13029 Human
SwissProt: Q63755 Rat
Unigene: 371823 Human
Unigene: 202632 Rat
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