Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
Function:
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
Subunit:
May interact with GNB2L1, ZFYVE9 and NMRK2
Subcellular Location:
Membrane; Single-pass type I membrane protein. Membrane, coated pit.
Tissue Specificity:
Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.
Similarity:
Belongs to the LDLR family.
Contains 2 CUB domains.
Contains 5 LDL-receptor class A domains.
SWISS:
Q9Y561
Gene ID:
29967
Database links:
Entrez Gene: 29967 Human
Entrez Gene: 239393 Mouse
Entrez Gene: 314941 Rat
SwissProt: Q9Y561 Human
SwissProt: Q8BUJ9 Mouse
Unigene: 600630 Human
Unigene: 715867 Human
Unigene: 39874 Mouse
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