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Home > Product > Antibody > Rabbit Anti-SHPRH antibody
E3 ubiquitin-protein ligase SHPRH; histone-linker; PHD and RING finger domain-containing helicase; SNF2; SNF2 histone linker PHD RING helicase; SHPRH_HUMAN.
Cat:
SL6104R
Species Reactivity：
(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human SHPRH:401-500/1683
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
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Product PDFs
Datasheet:


SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5

Function:
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.

Subunit:
Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18.

Tissue Specificity:
Broadly expressed.

Similarity:
Belongs to the SNF2/RAD54 helicase family.
Contains 1 H15 (linker histone H1/H5 globular) domain.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
Contains 1 PHD-type zinc finger.
Contains 1 RING-type zinc finger.

SWISS:
Q149N8

Gene ID:
257218

Database links:

Entrez Gene: 257218 Human

Omim: 608048 Human

SwissProt: Q149N8 Human

Unigene: 723297 Human



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