Tomoregulin-1 precursor is a single-pass type I membrane protein thought to be a tumor suppressor in brain cancers. Its expression is down-regulated in these tumors as compared to control brain tissues. In addition, it might also inhibit NODAL and BMP signaling during neural patterning. There are 2 isoforms produced by alternative splicing.
Function:
May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers.
Subunit:
May interact with ST14.
Subcellular Location:
Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted.
Tissue Specificity:
Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.
Similarity:
Belongs to the tomoregulin family.
Contains 1 EGF-like domain.
Contains 2 Kazal-like domains.
SWISS:
Q8IYR6
Gene ID:
8577
Database links:
Entrez Gene: 100526694 Human
Entrez Gene: 8577 Human
Entrez Gene: 230157 Mouse
Entrez Gene: 63845 Rat
Omim: 603421 Human
SwissProt: Q8IYR6 Human
SwissProt: Q6PFE7 Mouse
SwissProt: Q9QYV1 Rat
Unigene: 598100 Human
Unigene: 422686 Mouse
Unigene: 162809 Rat
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