Rabbit Anti-DIRAS1 antibody

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Di Ras1; DIRAS family GTP binding RAS like 1; Distinct subgroup of the Ras family member 1; GBTS1; GTP binding protein Di Ras1; Ras related inhibitor of cell growth; RIG; Rig protein; Small GTP binding tumor suppressor 1.

Cat:

SL6163R

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human DIRAS1:21-120/198

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The three human RAS genes encode highly related 188 to 189 amino acid proteins, designated H-Ras, N-Ras and K-Ras4A and K-Ras4B (the two K-Ras proteins arise from alternative gene splicing). Ras proteins function as binary molecular switches that control intracellular signaling networks. Ras-regulated signal pathways control such processes as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. Ras and ras-related proteins are often deregulated in cancers, leading to increased invasion and metastasis, and decreased apoptosis. DIRAS1 displays low GTPase activity and exists predominantly in the GTP-bound form. It is highly expressed in heart and brain.

Function:
Displays low GTPase activity and exist predominantly in the GTP-bound form.

Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).

Tissue Specificity:
Highly expressed in heart and brain.

Similarity:
Belongs to the small GTPase superfamily. Di-Ras family.

SWISS:
O95057

Gene ID:
148252

Database links:

Entrez Gene: 148252 Human

Omim: 607862 Human

SwissProt: O95057 Human

Unigene: 172753 Human

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