The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
Function:
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).
Subunit:
Interacts with stathmin and CDKN1B/p27Kip1 (By similarity).
Subcellular Location:
Nucleus. Note=Mostly nuclear (By similarity).
Tissue Specificity:
Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
Q8TAS1
Gene ID:
127933
Database links:
Entrez Gene: 127933 Human
Entrez Gene: 16589 Mouse
Entrez Gene: 246332 Rat
Omim: 608849 Human
SwissProt: Q8TAS1 Human
SwissProt: P97343 Mouse
SwissProt: Q63285 Rat
Unigene: 127310 Human
Unigene: 209150 Mouse
Unigene: 389214 Mouse
Unigene: 89229 Rat
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