DCUN1D1 (DCUN1 domain-containing protein 1) contains a DUF298 domain and a UBA-like ubiquitin. Forms part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. Defects in DCUN1D1 may be a cause of squamous cell carcinomas.
Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.
Subunit:
Part of an E3 complex for neddylation composed of cullins, RBX1, UBE2M and CAND1. Interacts (via the SLCterminus 50 AA) with CUL1, CUL2, CUL3, CUL4 and CUL5. Binds neddylated CUL1. Interacts (via the SLCterminus 50 AA) directly with RBX1. Interacts preferentially with UBE2M-NEDD8 thioester (via N-terminus 1-26 AA) than with free UBE2M. Interacts with CAND1 when in complex with CUL1-RBX1.
Tissue Specificity:
Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.
Similarity:
Contains 1 DCUN1 domain.
Contains 1 UBA-like domain.
SWISS:
Q96GG9
Gene ID:
54165
Database links:
Entrez Gene: 54165 Human
Entrez Gene: 114893 Mouse
Entrez Gene: 310324 Rat
Omim: 605905 Human
SwissProt: Q96GG9 Human
SwissProt: Q9QZ73 Mouse
Unigene: 104613 Human
Unigene: 374810 Mouse
Unigene: 379305 Mouse
Unigene: 474495 Mouse
Unigene: 116073 Rat
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